To bring pain care to the standard we've already set for diabetes, heart disease, and every other dynamic condition.
“Medicine asks you to make perfect decisions with imperfect information.”*
*Siddhartha Mukherjee, The Laws of Medicine
The scope of the problem
Americans report chronic pain
Wait 1-5 Years for a Diagnosis.
the annual cost to the United States.
Because
The gold standard for pain care is still “Pick a number between 0 - 10.”
Despite the complexity of pain
01
Nociceptive pain
Tissue Damage
Sprains, fractures, arthritis, post-surgical pain.
02
Neuropathic pain
Nerve Damage
Spinal cord injury pain, diabetic neuropathy, post-herpetic neuralgia, sciatica.
03
Nociplastic pain
Altered Pain Processing
Fibromyalgia, irritable bowel syndrome, many chronic low back pain cases.
What that cost us
That subjectivity has driven years of misdiagnosis and noisy clinical trials.
Drug/Neuromodulation Devices
In development
Pain care reimagined
OBJECTIVE PAIN INTELLIGENCE
Physiology
Clinical Wearable
Continuous physiological monitoring
Experience
Patient app
Lived Experience of Pain
Diagnostics
Clinical Platform
Built for clinicians to review a patient's record over time.
Intelligence
AI
Working toward a structured, longitudinal pain signal, validated in clinical studies.
Pain has never been labeled in the real world. until now.
THE STORY OF PAIN
1921
Visual Analog Scale
Hayes and Patterson introduced the Visual Analog Scale, a 100mm line from no pain to worst pain imaginable that patients mark to self-report intensity.
1983
Wong-Baker FACES Scale
Donna Wong and Connie Baker developed the FACES Pain Rating Scale for pediatric patients, later adapted to a 0-2-4-6-8-10 numeric scale for easier charting.
2013
fMRI Neurologic Pain Signature
fMRI-based neurologic signature of physical pain in the New England Journal of Medicine
2016
fMRI Distinguishes Real Drug Effects
fMRI with capsaicin-induced sensitization to show gabapentin, but not ibuprofen or placebo, altered pain-related brain activity
2020
Protein and Proteomic Biomarker Panels
Researchers increasingly studied CRP, IL-6, and TNF-alpha as the most consistent inflammatory correlates of chronic musculoskeletal pain, alongside multi-protein and microRNA panels.
2025
Large-Scale Blood Biomarker Prediction study
The synthesis of evidence from systematic reviews and meta-analyses concludes that no single biomarker for chronic pain has achieved sufficient prospective validation for routine clinical use
2026
Objective Pain Intelligence
Our goal: an objective, real-world measure of pain, validated in clinical studies.
TEAM
Built by engineers, clinicians, and scientists from Weill Cornell Medicine, Harvard, Pratt, Amazon, and Medtronic.
ADVISORS
Leading experts across clinical pain, trial design, and regulatory.
NOCI
MAKING PAIN MEASURABLE
Regulatory Status: Noci technology is under development and has not been cleared or approved by the U.S. Food and Drug Administration (FDA). No Noci device is commercially available.No Medical Advice: The information on this website is provided for informational purposes only and is not medical advice. Patients should consult a qualified healthcare professional regarding diagnosis and treatment decisions.
Noci Corporation. All Rights Reserved.
To bring pain care to the standard we've already set for diabetes, heart disease, and every other dynamic condition.
“Medicine asks you to make perfect decisions with imperfect information.”*
*Siddhartha Mukherjee, The Laws of Medicine
The scope of the problem
of US adults live with chronic pain.
wait more than a year for a diagnosis.
the annual cost to the United States.
Because
The gold standard for pain care is still “Pick a number between 0 - 10.”
Despite the complexity of pain
01
Nociceptive pain
Tissue Damage
Sprains, fractures, arthritis, post-surgical pain.
02
Neuropathic pain
Nerve Damage
Spinal cord injury pain, diabetic neuropathy, post-herpetic neuralgia, sciatica.
03
Nociplastic pain
Altered Pain Processing
Fibromyalgia, irritable bowel syndrome, many chronic low back pain cases.
What that cost us
That subjectivity has driven years of misdiagnosis and noisy clinical trials.
Drug/Neuromodulation Devices
In development
Pain care reimagined
OBJECTIVE PAIN INTELLIGENCE
Physiology
Clinical Wearable
A ring designed for continuous physiological monitoring, at home and in the clinic.
Experience
Patient app
Working toward capturing the patient's lived experience of pain, alongside their physiology.
Diagnostics
Clinical Platform
Built for clinicians to review a patient's record over time.
Intelligence
AI
Working toward a structured, longitudinal pain signal, validated in clinical studies.
Pain has never been labeled in the real world. That’s what we’re building.
THE STORY OF PAIN
TEAM
Built by engineers, clinicians, and scientists from Weill Cornell Medicine, Harvard, Pratt, Amazon, and Medtronic.
ADVISORS
Leading experts across clinical pain, trial design, and regulatory.
NOCI
MAKING PAIN MEASURABLE
Regulatory Status: Noci technology is under development and has not been cleared or approved by the U.S. Food and Drug Administration (FDA). No Noci device is commercially available.No Medical Advice: The information on this website is provided for informational purposes only and is not medical advice. Patients should consult a qualified healthcare professional regarding diagnosis and treatment decisions.
Noci Corporation. All Rights Reserved.
To bring pain care to the standard we've already set for diabetes, heart disease and every other dynamic condition.
"Medicine asks you to make perfect decisions with imperfect information."
*Siddhartha Mukherjee, The Laws of Medicine
The scope of the problem
of US adults live with chronic pain.
wait more than a year for a diagnosis.
the annual cost to the United States.
Because
The gold standard for pain care is still “Pick a number from 0 - 10.”
Despite the complexity of pain
01
Nociceptive pain
Tissue Damage
Sprains, fractures, arthritis, post-surgical pain.
02
Neuropathic pain
Nerve Damage
Spinal cord injury pain, diabetic neuropathy, post-herpetic neuralgia, sciatica.
03
Nociplastic pain
Altered Pain Processing
Fibromyalgia, irritable bowel syndrome, many chronic low back pain cases.
What that cost us
That subjectivity has driven years of misdiagnosis and noisy clinical trials.
Drug/Neuromodulation Devices
In development
Pain care reimagined
OBJECTIVE PAIN INTELLIGENCE
Physiology
Clinical Wearable
A ring designed for continuous physiological monitoring, at home and in the clinic.
Experience
Patient app
Working toward capturing the patient's lived experience of pain, alongside their physiology.
Diagnostics
Clinical Platform
Built for clinicians to review a patient's record over time.
Intelligence
AI
Working toward a structured, longitudinal pain signal, validated in clinical studies.
Pain has never been labeled in the real world. That’s what we’re building.
THE STORY OF PAIN
TEAM
Built by engineers, clinicians, and scientists from Weill Cornell Medicine, Harvard, Pratt, Amazon, and Medtronic.
ADVISORS
Leading experts across clinical pain, trial design, and regulatory.
NOCI
Regulatory status: Noci technology is under development and has not been cleared or approved by the U.S. Food and Drug Administration (FDA). No Noci device is commercially available.
No medical advice: The information on this website is provided for informational purposes only and is not medical advice. Patients should consult a qualified healthcare professional regarding diagnosis and treatment decisions.
MAKING PAIN MEASURABLE
Noci Corporation. All Rights Reserved.